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KMID : 0895420090190010030
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Journal of Korean Society of Occupational and Enviromental Hygiene
2009 Volume.19 No. 1 p.30 ~ p.38
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Changes of physiological levels of the risk factors contributing to induction of metabolic syndrome in workers chronically exposed to styrene
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Heo Kyung-Hwa
Koo Jung-Wan
Won Yong-Rim
Kim Min-Gi
Ko Kyung-Sun
Lee Mi-Young
Kim Tae-Gyun
Kim Ki-Woong
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Abstract
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The objective of this study was to evaluate the effects of occupational exposure to styrene on the components of metabolic syndrome. We surveyed 263 employees, among whom 117workers we ere chronically exposed to styrene in glass-reinforced plastic boat manufacturing factories and 146 controls had never been occupationally exposed to styrene as will as hazardous chemicals. The general and job characteristics such as age, smoking and drinking habit, working hours and duration were not significant different except sleeping hours(p<0.05). Among the components of metabolic syndrome, the systolic blood pressure, total cholesterol, HDL-cholesterol and fasting glucose were significantly higher in exposed workers. On multiple logistic regression analysis for the components of metabolic syndrome, waist circumference was insulin (OR=1.129), blood pressure was MA(OR=14.724), fasting glucose(OR=1.191) and metabolic syndrome(OR=1.110) were significantly associated with insulin. The mean concentration of airborne styrene was 38.1±40.1 ppm, blood concentrations of glucose and insulin and levels of HOMA-IR in over 50 ppm exposed group were higher than in blow 50 ppm exposed group. These results suggested that the exposure of styrene affects blood pressure, fasting glucose and insulin levels and that dysfunction and/or declination in glucose and insulin metabolism might induced ultimately insulin resistance and metabolic syndrome.
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KEYWORD
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Styrene, Insulin, HOMA-IR, Metabolic syndrome, Workers
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